Chelsea will be without Frank Lampard, Didier Drogba, Michael Ballack and Deco against Wolves.
Drogba is back in training after the rib injury he received against Manchester United but will be out for another week while Ballack (knee) should be back for the Champions League match against Porto on Wednesday.
Lampard (thigh) is expected to be out for three weeks. Youngsters Fabio Borini, Nemanja Matic and Gael Kakuta are all expected to feature from the bench against Wolves.
Wolves are boosted by the return of right-back Kevin Foley.
Foley has only made three appearances this season after twice suffering knee ligament problems and his return could not be better timed as defender Ronald Zubar is a major doubt after picking up a thigh strain in training this week.
Wolves are definitely without on-loan Chelsea central defender Michael Mancienne who cannot face his parent club.
Manager Mick McCarthy could also opt to rest striker Kevin Doyle after his two games for the Republic of Ireland against France and start him on the bench.
Teams:
Chelsea (from): Cech, Ivanovic, Carvalho, Terry, Alex, A Cole, Essien, J Cole, Anelka, Kalou, Borini, Matic, Kakuta, Hilario, Ferreira, Mikel Obi, Malouda.
Wolves (from): Hennessey, Hahnemann, Zubar, Foley, Stearman, Berra, Craddock, Elokobi, Kightly, Halford, Henry, Milijas, Castillo, Edwards, Jarvis, Ebanks-Blake, Keogh, Maierhofer, Doyle.